The closest the series comes to addressing the issue was when Osaka asked Kaorin if she was gay, in the '10th Anniversary Omnibus'. Azumanga Daioh: The only reason Kaorin's orientation is ambiguous, is because it was never confirmed whether she's actually in love with Sakaki, or simply fangirling really, REALLY, hard over her.Moe compares them to a married couple, while others tend to see their relationship as platonic.
While everyone in the cast knows Mira and Ao are very close, they have different views on the nature of their relationship. An In-Universe case appears in Asteroid in Love.
